A Simple In Vivo Atrial Fibrillation Model of Rat Induced by Transesophageal Atrial Burst Pacing

Journal of Pharmacological Sciences

Sachiko Honsho¹  Yuji Nakamura¹  Keitaro Hashimoto¹  Akira Takahara¹  Atsushi Sugiyama¹ 

[1] Department of Pharmacology, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi

关键词: atrial fibrillation;    pilsicainide;    pentobarbital;   

DOI  :  10.1254/jphs.SCJ05002X

学科分类：药学

来源: Nihon Yakuri Gakkai Henshuubu / Japanese Pharmacological Society

【 摘 要 】

References(15)Cited-By(5)A simple in vivo closed-chest atrial fibrillation (Af) model of rats was developed. Af was reproducibly induced by transesophageal atrial burst pacing for 30 s in each of the pentobarbital-anesthetized rats, whereas the cardiohemodynamic condition as well as the inducibility and duration of Af episode was stable over time. Moreover, the anti-Af effect of the class Ic drug pilsicainide was confirmed in this model, which was essentially the same as those reported previously in other Af animal models and clinical practice. Thus, this new model may become an alternative to current techniques.

【 授权许可】

Unknown