Disseminated Histiocytic Sarcoma with Excessive Hemophagocytosis in a Cat

Journal of Veterinary Medical Science

Koichi OHNO¹  Hajime TSUJIMOTO¹  Koji UETSUKA²  Takayuki NAKAGAWA⁴  Asuka SETOGUCHI-MUKAI³  Hiroyuki NAKAYAMA²  Kaori IDE¹  Yasuhito FUJINO¹ 

[1] Department of Veterinary Internal Medicine, Graduate School of Agricultural and Life Sciences, The University of Tokyo;Department of Veterinary Pathology, Graduate School of Agricultural and Life Sciences, The University of Tokyo;Department of Veterinary Internal Medicine, Faculty of Agriculture, Kagoshima University;Department of Veterinary Surgery, Graduate School of Agricultural and Life Sciences, The University of Tokyo

关键词: feline;    hemophagocytosis;    histiocytic sarcoma;   

DOI  :  10.1292/jvms.71.817

学科分类：兽医学

来源: Japanese Society of Veterinary Science

【 摘 要 】

References(23)Cited-By(5)A 10-year-old Japanese domestic cat was presented with anorexia and weight loss. Severe anemia and thrombocytopenia were detected. Abdominal radiography and ultrasonography revealed the presence of multiple masses in the spleen. Cytological analyses of the masses revealed several atypical histiocytic cells and considerable hemophagocytosis. A splenectomy was performed, and the mass was diagnosed as histiocytic sarcoma on the basis of histopathological, cytochemical and immunohistochemical analyses. Further, abnormal hemophagocytosis was observed in the bone marrow. The cat was administered prednisolone and lomustine, and it survived for 107 days after admission. An autopsy revealed the presence of neoplastic histiocytic cells in the bone marrow, liver, pancreatic lymph node and glomeruli. This is the first case of histiocytic sarcoma in a cat to be reported in Japan.

【 授权许可】

Unknown