Effect of Lacto-N-biose I on the Antigen-specific Immune Responses of Splenocytes

Bioscience of Microbiota, Food and Health

Masao GOTO¹  Mamoru NISHIMOTO¹  Motomitsu KITAOKA¹  Yuko TAKANO-ISHIKAWA¹ 

[1] National Agriculture and Food Research Organization National Food Research Institute

关键词: LNB;    IL-4;    naïve immune cells;    anti-allergy;   

DOI  :  10.12938/bmfh.31.47

学科分类：生物科学（综合）

来源: Nihon Bifizusukin Senta / Japan Bifidus Foundation

【 摘 要 】

References(24)We examined the effect of lacto-N-biose I (LNB) on Antigen (Ag)-specific responses of immune cells. LNB exposure in vitro suppressed Ag-specific Interleukin (IL)-4 secretion of mouse splenocytes significantly. However, IL-4 secretion from CD4+ T cells stimulated with anti-CD3ε did not changed significantly with LNB exposure. Additionally, Ag-specific Th1 cytokines did not change. Therefore LNB might suppress Ag-specific IL-4 through modification of Ag-presenting cells (APCs) in a manner independent of Th1-type immune development.

【 授权许可】

Unknown