Prophylactic effect of levamisole on rainbow trout (Oncorhynchus mykiss) against Yersinia ruckeri

Pesquisa Veterinária Brasileira

Ispir, Unal¹ 

[1] Bingol University, Bingol, Turkey

关键词: Levamisole;    rainbow trout;    Oncorhynchus mykiss;    Yersinia ruckeri;    immunity;    protection;   

DOI  :  10.1590/S0100-736X2009000900003

来源: Colegio Brasileiro de Patologia Animal-CBPA

【 摘 要 】

Alteration in the relative percentage of survival (RPS) rate of rainbow trout (Oncorhynchus mykiss) exposed to 5, 10 and 25µg ml-1 levamisole for 2 h against Yersinia ruckeri was investigated. The average weight of the 120 fish used in this study was 6.3g. Upon challenge with a virulent strain, the relative survival percentage of respectively 83.3%, 86.7% and 76.6% was recorded. The results suggest that the application of levamisole in fish farms could increase resistance to infection of fish and offer economic benefits. INDEX TERMS: Levamisole; rainbow trout;Oncorhynchus mykiss;Yersinia ruckeri; immunity; protection    INTRODUCTION Antibiotics, drugs and chemicals have been used for treating fish disease caused by environmental stress and other factors for years. However, these are often effective for only a short time and may accumulate in the environ-ment. In the past, the immunological approach to preventing fish disease has been by vaccination against specific pathogens, where vaccines were used for treating a particular disease (Siwicki et al. 1994). Immunostimulants is important to health as provides the building block of defence mechanisms and protection against disease several promising adjuvants, natural and synthetic drugs and biological modifiers have been tested in fish in vivo and in vitro. The substance are effective in stimulating or modulating non-specific defence mechanism, and offer protection against viral and bacterial diseases fish (Kodama et al. 1993, Siwicki et al. 1994, Mulero et al. 1998, Cuesta et al. 2002a). Levamisole is a levo-isomer of tetramisole [6]. Previous studies have suggested that levamisole treatment leads to an enhanced state of resistance to various kinds of infections (Jeney et al. 1994, Mulero et al. 1998, Findlay & Mundlay 2000). Levamisole is a registered and accepted drug for the Europen Comminity and the United States Food and Drug Administration, its metabolism is not well known. Toxicity and tissue residues have been reported after its use in some animals but not for fish (Cuesta et al. 2002b). The purpose of this study was to determine the influence of bath the levamisole on prophylactic effect Yersinia ruckeri in the intensive culture of rainbow trout (Oncorhynchus mykiss). MATERIALS AND METHODS Healty Oncorhynchus mykiss avarege weighing 6.3g, were obtained from local fish farming, Elazig, Tur

【 授权许可】

CC BY-NC