Effect of Topical Administration of 0.8% Nalbuphine on the Cornea in Dogs after Phacoemulsification

Journal of Veterinary Medical Science

Chen-Han LEE¹  Shiun-Long LIN¹  Ting-Ting CHI²  Shu-Hao CHANG²  Hsien-Chi WANG¹ 

[1] Department of Veterinary Medicine, College of Veterinary Medicine, National Chung-Hsing University, 250–1 Kuo Kuang Road, Taichung 402, Taiwan;Veterinary Medicine Teaching Hospital, College of Veterinary Medicine, National Chung-Hsing University, 250–1 Kuo Kuang Road, Taichung 402, Taiwan

关键词: canine;    corneal sensitivity;    nalbuphine;    phacoemulsification;    topical;   

DOI  :  10.1292/jvms.12-0125

学科分类：兽医学

来源: Japanese Society of Veterinary Science

【 摘 要 】

References(23)Cited-By(1)Supplementary materials(1)It is suggested that topical application of opioids may provide localized analgesia without delay in corneal wound healing. This study was designed to evaluate the effect of topical application of 0.8% nalbuphine on post-operative ocular pain in dogs. Twelve eyes from 11 dogs undergoing phacoemulsification cataract surgery were divided into a nalbuphine group (n=6) and saline group (n=6). Postoperatively, the nalbuphine group received 0.1 ml of topical 0.8% alkalinized nalbuphine (pH 5.6) every 8 hr, and the saline group received 0.1 ml of topical saline (pH 5.9) as a placebo. All dogs received systemic postoperative pain managements with oral tramadol (4 mg/kg) and prednisolone (0.5 mg/kg) every 8 hr. All dogs received pre- and post-ophthalmic examinations. Pain was scored in the dogs using a pain scoring system modified from the University of Melbourne pain scale at 15, 30 and 60 min following the topical treatment on days 1 and 2 (24 and 48 hr after surgery). Eye blink frequency and corneal touch threshold (CTT) were recorded at the same time. There was no statistical difference in the pain score between groups. Significant decreases in CTT, blepharospasm and eye blink frequency were observed after the topical nalbuphine treatment. This indicated that topical application of 0.8% nalbuphine solution can produce a rapid reduction of corneal discomfort in dogs.

【 授权许可】

Unknown