Oral Administration of T Cell Epitope Peptide Inhibits the Systemic IL-4Response Elicited by an Egg-White Diet in a TCR Transgenic Mouse Model

Bioscience of Microbiota, Food and Health

Haruyo NAKAJIMA-ADACHI¹  Erika HIRAIDE¹  Satoshi HACHIMURA¹ 

[1] Research Center for Food Safety, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-8657, Japan

关键词: food allergy;    oral immunotherapy;    ovalbumin;    T cell epitope;    TCR transgenic mice;   

DOI  :  10.12938/bmfh.33.47

学科分类：生物科学（综合）

来源: Nihon Bifizusukin Senta / Japan Bifidus Foundation

【 摘 要 】

References(12)Oral immunotherapy with T cell epitope peptides is a promising treatment for foodallergy. We examined the effect of oral administration of an ovalbumin T cell epitopepeptide (OVA323-339) in a TCR transgenic mouse model (OVA23-3 mice). OVA23-3 mice were fedegg-white diet containing ovalbumin and subsequently orally administrated the OVA323-339peptide. Cytokine measurements revealed that the IL-4 production of splenicCD4+ T cells was significantly decreased by feeding the OVA323-339 peptide.Our study suggested that oral administration of the OVA323-339 T cell epitope peptide wascapable of inhibiting systemic IL-4 response after elicitation of predominant Th2responses.

【 授权许可】

Unknown