期刊论文详细信息
Journal of Veterinary Medical Science
Prevention of Orotic-Acid-Induced Fatty Liver in Male Rats by Dehydroepiandrosterone and/or Phenobarbital
Takashi MAKITA2  Hirohiko GOTO2  Shuji YAMASHITA1 
[1] Tokushima Research Institute, Otsuka Pharmaceutical Co., Ltd.;The United Graduate School of Veterinary Science, Yamaguchi University
关键词: dehydroepiandrosterone;    fatty liver;    orotic acid;    peroxisome proliferator;    phenobarbital;   
DOI  :  10.1292/jvms.60.513
学科分类:兽医学
来源: Japanese Society of Veterinary Science
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【 摘 要 】

References(32)Cited-By(5)Dehydroepiandrosterone (DHEA) is a steroid hormone which induces the peroxisome proliferation in rodents. The fatty liver induced by orotic acid and a high sucrose diet in male rats was prevented by the administration of DHEA and/or phenobarbital (PB). A significant increase in the liver weight was induced in the DHEA group (relative weight) and the DHEA + PB group (absolute and relative weight). The liver weight increased more conspicuously in the DHEA + PB group than in the DHEA group. The increase in the liver weight was caused by an increase in the cell size and peroxisome number. In addition, the administration of DHEA alone and the combination of DHEA and PB prevented the lipid droplet accumulation in hepatocytes. The administration of PB alone also prevented the accumulation of lipid droplets without any increase in the liver weight.

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