Preliminary Immunohistochemical Study of Natriuretic Peptide Receptor Localization in Canine and Feline Heart

Journal of Veterinary Medical Science

Hajime AMASAKI²  Motoharu OISHI²  Hajime INOUE²  Satoshi SOETA²  Tetsuya YAMANE²  Naoyuki TAKEMURA¹ 

[1] Laboratory of Veterinary Integrate Medicine, Nippon Veterinary and Life Science University;Laboratory of Veterinary Anatomy, Nippon Veterinary and Life Science University

关键词: canine;    feline;    heart;    immunohistochemistry;    NPRs;   

DOI  :  10.1292/jvms.10-0114

学科分类：兽医学

来源: Japanese Society of Veterinary Science

【 摘 要 】

References(16)Cited-By(2)We examined the immunohistochemical distributions of natriuretic peptide receptor (NPR)-A, -B and -C that bind with natriuretic peptide hormones A, B and C in four healthy crossbreed young canine and feline cardiac tissues using specific antibodies against human antigens. Cross-immunoreactivities between antigens and antibodies were confirmed using western blot analysis. NPR-A and -C were expressed more strongly in dogs than cats. In both species, these expressions were stronger in the atria than the ventricles, with stronger expression in the left ventricles than the right. NPR-B was largely very weekly or undetected. In canine and feline cardiac tissues, the expressional distribution of NPR-A, -B, and -C closely matched with that of atrial natriuretic peptide, brain natriuretic peptide, and C-type natriuretic peptide as the ligands for corresponding receptors.

【 授权许可】

Unknown