Hyperleptinemia as a Robust Risk Factor of Coronary Artery Disease and Metabolic Syndrome in Type 2 Diabetic Patients

Endocrine Journal

Sung-Kil LIM³  Chul-Woo AHN³  Bong-Soo CHA³  Hyun-Chul LEE³  Seok-Won PARK¹  Yong-Wook CHO¹  Soo-Kyung KIM¹  Hae-Jin KIM² 

[1] Department of Internal Medicine, College of Medicine, Pochon CHA University;Department of Internal Medicine, Ajou University School of Medicine;Brain Korea 21 Project for Medical Science, Yonsei University College of Medicine

关键词: Coronary artery disease;    Hyperleptinemia;    Insulin resistance;    Metabolic syndrome;   

DOI  :  10.1507/endocrj.K08E-182

学科分类：内分泌与代谢学

来源: Japan Endocrine Society

【 摘 要 】

References(34)Cited-By(10)Leptin has been linked to adiposity, insulin resistance, and coronary artery disease (CAD). We examined whether the leptin concentrations are associated with the risk of CAD and metabolic syndrome (MS). The plasma leptin concentrations were measured in 556 diabetic patients (341 men and 215 women). The odds ratio (OR) of CAD and MS were increased on moving from the lowest quartile (Q1) of leptin concentration to the highest quartile (Q4) and remained significant after adjusting for age, sex, BMI, concentrations of total cholesterol, triglyceride, or high-sensitivity C-reactive protein (hsCRP), and treatment modalities for hyperglycemia. The frequency of CAD was highest in the insulin resistant group (Q4 of homeostasis model assessment-insulin resistance index [HOMA-IR]) at Q4 of leptin concentration (34.5%), compared with that of Q4 of leptin (26.4%) or HOMA-IR (21.9%). In multivariate analysis, plasma leptin concentration was identified as the most significantly independent predictor for CAD (OR 10.24, 95% CI 3.01 to 45.05). Other variables with associated with CAD were age, sex, hypertension, low-HDL cholesterolemia, and hsCRP. In conclusion, hyperleptinemia might be an independent risk factor for CAD and MS in diabetic subjects. And the simultaneous measurement of insulin resistance and leptin concentration might be helpful for screening subjects with a high-risk of CAD.

【 授权许可】

Unknown