Activation of Proteinase-Activated Receptors Induces Itch-Associated Response Through Histamine-Dependent and -Independent Pathways in Mice

Journal of Pharmacological Sciences

Jung-Bum Lee²  Tsugunobu Andoh¹  Yasushi Kuraishi¹  Kenichiro Tsujii¹ 

[1] Department of Applied Pharmacology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Japan;Department of Pharmacognosy, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Japan

关键词: proteinase-activated receptor subtype;    itch;    scratch;   

DOI  :  10.1254/jphs.08200SC

学科分类：药学

来源: Nihon Yakuri Gakkai Henshuubu / Japanese Pharmacological Society

【 摘 要 】

References(15)Cited-By(25)Proteinase-activated receptor-2 (PAR2) participates in itch, but the role of the other subtypes of this receptor remain unknown. To investigate this issue, scratching, an itch-related behavior, was observed following intradermal injections of the activating peptides of PAR1–4 in mice. Activating peptides of PAR1, PAR2, and PAR4, but not PAR3, induced scratching. The antihistamine terfenadine suppressed scratching elicited by activating peptides of PAR1 and PAR4, but not PAR2. These results suggest that PAR1, PAR2, and PAR4 are involved in itch and that histamine is a cause of itch related to PAR1 and PAR4, but not PAR2.

【 授权许可】

Unknown