Atopic NC/Nga Mice as a Model for Allergic Asthma: Cytokine Profiles and Eosinophil Productivity of Bone Marrow

Journal of Veterinary Medical Science

Akane TANAKA¹  Misao ONUMA²  Hiroshi MATSUDA¹  Tadashi IWASAKI² 

[1] Laboratory of Clinical Immunology, Department of Veterinary Clinic, Faculty of Agriculture, Tokyo University of Agriculture and Technology;Laboratory of Infectious Diseases, Department of Disease Control, Graduate School of Veterinary Medicine, Hokkaido University

关键词: asthma;    eosinophil;    NC/Nga mouse;   

DOI  :  10.1292/jvms.63.471

学科分类：兽医学

来源: Japanese Society of Veterinary Science

【 摘 要 】

References(32)Cited-By(6)In previous study, NC/Nga mice with experimentally induced asthma showed severe eosinophilia. To explore the mechanism, profiles of representative cytokines interleukin (IL)-4, IL-5, and interferon (IFN)-γ were examined in bronchoalveolar lavage fluid. The level of only IFN-γ was lower in NC/Nga mice than control BALB/c mice. Furthermore, bone marrow cell culture system under the presence of eosinopoietic cytokines, which induce the differentiation of progenitor cells into mature eosinophils, showed that a larger number of eosinophils differentiated from NC/Nga mice derived bone marrow cells than from control BALB/c mice. These results may imply the possibility that severe eosinophilia in the NC/Nga mice are attributable to lower production of IFN-γ and higher eosinophil productivity of bone marrow cells.

【 授权许可】

Unknown