The role of microRNAs in enteroviral infections

Brazilian Journal of Infectious Diseases

Wu, Jing¹  Mao, Lingxiang²  Shen, Li²  Xu, Huaxi¹  Chen, Jianguo³ 

[1] Jiangsu University, Zhenjiang, China;Zhenjiang Center for Disease Control and Prevention, Zhenjiang, China;Zhenjiang First People's Hospital, China

关键词: MicroRNAs;    Enterovirus;    Infection;   

DOI  :  10.1016/j.bjid.2015.06.011

来源: Contexto

【 摘 要 】

The genus Enterovirus, a member of thePicornavirus family, are RNA viruses that can cause poliomyelitis, hand-food-mouth disease, viral meningitis or meningoencephalitis, viral myocarditis and so on. MicroRNAs are a class of highly conserved, small noncoding RNAs recognized as important regulators of gene expression. Recent studies found that MicroRNAs play a significant role in the infection ofEnterovirus, such as enterovirus 71, coxsackievirus B3 and other Enterovirus. Enteroviral infection can alter the expression of cellular MicroRNAs, and cellular MicroRNAs can modulate viral pathogenesis and replication by regulating the expression level of viral or host's genes. Herein, this review summarizes the role of MicroRNAs in enteroviral infection.

【 授权许可】

Unknown