Pharmacological Topics of Bone Metabolism:Antiresorptive Microbial Compounds That Inhibit Osteoclast Differentiation, Function, and Survival

Journal of Pharmacological Sciences

Kazuo Nagai¹  Toshiaki Teruya¹  Je-Tae Woo¹  Takayuki Yonezawa¹  Byung-Yoon Cha¹ 

[1] Department of Biological Chemistry, Chubu University, Japan

关键词: microbial metabolite;    antiresorptive agent;    bone resorption;    osteoclast;    osteoporosis;    bone metabolism;   

DOI  :  10.1254/jphs.FM0070288

学科分类：药学

来源: Nihon Yakuri Gakkai Henshuubu / Japanese Pharmacological Society

【 摘 要 】

References(34)Cited-By(12)The mass and function of bones depends on the maintenance of a complicated balance between osteoclast-mediated bone resorption and osteoblast-mediated bone formation. Osteoporosis typically reflects an imbalance in skeletal turnover, such that bone resorption exceeds bone formation. Osteoclasts are target cells for anti-osteoporosis therapies. To discover new types of antiresorptive agents, we screened for natural compounds that regulate osteoclast differentiation, function, and survival. As a result, we identified reveromycin A, destruxins, mevastatin, FK506, cyclosporin A, prodigiosins, concanamycins, and symbioimine among microbial natural compounds. In this review, we discuss the mechanisms of action of these compounds on osteoclasts.

【 授权许可】

Unknown