Association of Protein Tyrosine Phosphatase Nonreceptor 22 (PTPN22) C1858T gene polymorphism with susceptibility to autoimmune thyroid diseases: a meta-analysis

Endocrine Journal

Xin Hu¹  Fei Liu²  Bei Cai³  Lanlan Wang³  Limei Luo³ 

[1] Department of Neurosurgery, West China Hospital, Sichuan University, 610041, China;Department of Liver and Vascular Surgery, West China Hospital, Sichuan University, 610041, China;Department of Clinical Immunological Laboratory, West China Hospital, Sichuan University, 610041, China

关键词: Protein tyrosine phosphatase nonreceptor 22;    Polymorphism;    Meta-analysis;    Autoimmune thyroid diseases;   

DOI  :  10.1507/endocrj.EJ11-0381

学科分类：内分泌与代谢学

来源: Japan Endocrine Society

【 摘 要 】

References(29)Cited-By(8)Results from studies on the association of PTPN22 C1858T polymorphism with AITD risk are conflicting, we thereby perform this meta-analysis to derive a more precise effect on this possible association.Two investigators independently searched the PubMed, Embase, Wanfang and CNKI (China National Knowledge Infrastructure) databases.A total of 11 studies with 3764 AITDs cases and 3328 controls were finally identified.Statistically significant association was observed between PTPN22 C1858T polymorphism and AITD risk based on all studies (TT vs. CC, OR=2.18, 95%CI=1.31˜3.62; TC vs. CC, OR=1.50, 95%CI=1.29˜1.73; TT/TC vs. CC, OR=1.41, 95%CI=1.12˜1.78; TT vs. TC/CC, OR=2.00, 95%CI=1.21˜3.33).The results of subgroup analysis showed that: (1) regarding ethnic diversity, the variant genotypes TT/TC of C1858T were associated with a significantly increased AITD risk in Caucasians (TT/TC vs. CC, OR=1.41, 95%CI=1.09˜1.83) (2) regarding different countries, the statistically significantly association was observed in UK (TC vs. CC, OR=1.64, 95%CI=1.36˜1.98; TT/TC vs. CC, OR=1.65, 95%CI=1.37˜1.98) and other countries (including South Tunisia, Russia, Polish, Japanese) (TT vs. CC, OR=3.65, 95%CI=1.43˜9.33; TT vs. TC/CC, OR=3.41, 95%CI=1.34˜8.65).(3) regarding the subtypes of AITDs, patients with Graves’ disease (GD) had a significant higher degree of C1858T polymorphism (TT vs. CC, OR=2.35, 95%CI=1.36˜4.05; TC vs. CC, OR=1.46, 95%CI=1.12˜1.89; TT/TC vs. CC, OR=1.54, 95%CI=1.33˜1.80; TT vs. TC/CC, OR=2.16, 95%CI=1.25˜3.72), while no association was observed in patients with Hashimoto’s thyroiditis (HT).No publication bias was observed.Our results demonstrated that PTPN22 C1858T polymorphism was associated with AITD risk, especially in Caucasians.

【 授权许可】

Unknown