Cutaneous cytomegalovirus infection in a child with hyper IgE and specific defects in antibody response to protein vaccines

Brazilian Journal of Infectious Diseases

Pournasir, Zahra³  Rezaei, Nima²  Chavoshzadeh, Zahra¹  Fallah, Shahrzad³  Tabatabaei, Ahmad³ 

[1] Shaheed Beheshti University of Medical Sciences;Tehran University of Medical Sciences, Tehran, Iran;Shaheed Beheshti University of Medical Sciences, Tehran, Iran

关键词: cytomegalovirus infections;    antibody formation;    common variable immunodeficiency.;   

DOI  :  10.1590/S1413-86702011000500013

来源: Contexto

【 摘 要 】

Cytomegalovirus (CMV) infection is a common opportunistic systemic infection in immunocompromised patients, but skin involvement is rare. Herein, we report a 10 year-old girl from consanguineous parents who was referred to our center because of disseminated maculopapular rash. She had history of upper and lower respiratory tract infections. In immunological studies, increased serum IgE level and decreased responses to tetanus and diphtheria were detected. Polymerase chain reaction (PCR) examination of bronchoalveolar lavage and serum sample revealed the presence of CMV. Early diagnosis of cutaneous CMV and appropriate treatment are the key actions in management of patients with underlying immunodeficiencies to avoid further complications.

【 授权许可】

CC BY-NC-ND