A Serosurvey of Borna Disease Virus Infection in Wild Rats by a Capture ELISA

Journal of Veterinary Medical Science

Jiro ARIKAWA³  Kumiko YOSHIMATSU³  Hisae INAGAKI¹  Michiko OGINO³  Hiroaki KARIWA¹  Ikuo TAKASHIMA²  Tetsuya MIZUTANI¹  Yuko MORII³ 

[1] Laboratory of Pablic Health, Department of Environmental Veterinary Sciences, The Graduate School of Veterinary Medicine, Hokkaido University, Sapporo 060-0818 Japan;Laboratory of Pablic Health, Department of Environmental Veterinary Sciences, The Graduate School of Veterinary Medicine, Hokkaido University, Sapporo 060-0818, Japan;Institute for Animal Experimentation, School of Medicine, Hokkaido University, Sapporo 060-8638, Japan

关键词: Borna disease virus;    capture ELISA;    Rattus norvegicus;   

DOI  :  10.1292/jvms.61.113

学科分类：兽医学

来源: Japanese Society of Veterinary Science

【 摘 要 】

References(23)Cited-By(8)For a serological diagnostic test for Borna disease (BD), we developed a capture ELISA with specificity and sensitivity based on detection of antibodies against BD virus (BDV) p40 protein. Using our capture ELISA system, the antibody response of rats inoculated intracerebrally with BDV at 4 weeks after birth showed a sharp increase from 1 to 4 weeks postinoculation (p.i.) and a steady level after 5 weeks p.i. To investigate prevalence of BDV infection among wild rats, we examined sera of Rattus norvegicus in Kami-iso town, Oshima district, Hokkaido, suggesting that rats in this area had not been infected by BDV.

【 授权许可】

Unknown