Immunogenicity of therapeutic protein aggregates

Medicina Fluminensis

Mijić, Ivana²  Marinc, Sabina¹  Cindrić, Mario² 

[1] Pliva Hrvatska d.d., Hrvatska;Insti tut “Ruđer Bošković�?, Zavod za molekularnu medicinu, Laboratorij za sistemsku biomedicinu,, Zagreb, Hrvatska

关键词: analytical methods;    antigen structure;    immunogenicity;    protein aggregation;   

DOI  :  

学科分类：环境科学（综合）

来源: Journal of Biopesticides

【 摘 要 】

Aggregati on is a signifi cant problem in pharmaceuti cal administrati on of proteins, since it can end up with several detrimental eff ects including the loss of acti vity, altered half-life in bloodstream, and increased immunogenicity....

【 授权许可】

Unknown