Plasma micronutrients are associated with dietary intake and environmental tobacco smoke exposure in a paediatric population

Public Health Nutrition

Heather Brady¹  Jill M Norris¹  Molly M Lamb¹  Marian J Rewers¹  Colleen A Ross¹  Jennifer A Seifert¹  Ronald J Sokol¹ 

关键词: Nutrient biomarker;    Environmental tobacco smoke;    Food-frequences questionnaire;    Children;    Dietary intake;   

DOI  :  10.1017/S1368980007662296

学科分类：卫生学

来源: Cambridge University Press

【 摘 要 】

BackgroundWhile adult populations have been well described in terms of nutritional status, such as the concentration of nutrient biomarkers, little work has been done in healthy paediatric populations.ObjectiveThe primary objective of this analysis was to explore the determinants of plasma micronutrients in a group of healthy infants and children.DesignThe Diabetes Autoimmunity Study in the Young (DAISY) has enrolled 1433 newborns at increased risk for type 1 diabetes in Denver, Colorado. A representative random sample of 257 children from the DAISY cohort between the ages of 9 months and 8 years with a total of 815 clinic visits over time was used in this analysis. Annual dietary intake was assessed over time with Willett food-frequency questionnaires that were validated in this population. Environmental tobacco smoke (ETS) was assessed using a validated survey. Plasma samples were tested for vitamins, carotenoids and total lipids. Predictors of plasma micronutrients were evaluated using mixed models for longitudinal data, while adjusting for age, human leukocyte antigen genotype, type 1 diabetes family history and other potential confounders and covariates.ResultsIncreased micronutrient intake was associated with increased levels of their respective plasma nutrient, with the exception of γ-tocopherol. Independent of dietary intake, levels of α- and β-carotene and β-cryptoxanthin were significantly lower, and γ-tocopherol was significantly higher, in children who were exposed to ETS.ConclusionDietary intake predicts plasma micronutrient levels. Exposure to ETS potentially could have negative health effects in this young population.

【 授权许可】

Unknown