A Case of Fulminant Type 1 Diabetes Associated With Significant Elevation of Mumps Titers

Endocrine Journal

Atsushi GOTO¹  Koji NAKANISHI²  Miyako KISHIMOTO¹  Yoshifumi NAKAJIMA¹  Hiroshi KAJIO¹  Mitsuhiko NODA¹  Yoshihiko TAKAHASHI¹ 

[1] Department of Diabetes and Metabolic Medicine, International Medical Center of Japan;Department of General Internal Medicine and Metabolism, Toranomon Hospital

关键词: Fulminant type 1 diabetes;    Type 1B diabetes;    Virus mediated etiology;    Mumps virus;   

DOI  :  10.1507/endocrj.K07E-126

学科分类：内分泌与代谢学

来源: Japan Endocrine Society

【 摘 要 】

References(10)Cited-By(10)Type 1 diabetes mellitus is classified as either autoimmune or idiopathic. Fulminant type 1 diabetes was originally reported as a subtype of idiopathic type 1 diabetes. Though involvement of viral infections has been suggested as a triggering mechanism, its pathogenesis remains unknown. Here, we present a case of fulminant type 1 diabetes associated with significant elevation of mumps titers. A 56-year-old Japanese man had suffered from nausea and generalized fatigue for two days before being transferred to our hospital in a confused state. Findings on admission revealed a high blood glucose level, near-normal HbA1c level, metabolic acidosis, and increased urinary ketone levels. Serum tests for islet-associated autoantibodies were negative. The serum, urinary C-peptide levels and the result of glucagon test indicated severe impairment of insulin secretion. These results were compatible with the diagnosis of fulminant type 1 diabetes. Also, he was suspected as having mumps infection on the basis of serological testing. These findings suggest that fulminant type 1 diabetes developed after mumps virus infection in our case. To the best of our knowledge, no other report has indicated an association between a recent mumps infection and the onset of fulminant type 1 diabetes. This case suggests an association between fulminant type 1 diabetes and mumps virus infection.

【 授权许可】

Unknown