TNF -308G > a promoter polymorphism (rs1800629) and outcome from critical illness

Brazilian Journal of Infectious Diseases

Fallavena, Paulo RV¹  Alho, Clarice Sampaio¹  Borges, Thiago J¹  Paludo, Francis JO¹  Dias, Fernando S¹  Picanço, Juliane B¹  Paskulin, Diego D'Ávila² 

[1] Pontifícia Universidade Católica do Rio Grande do Sul, Brazil;Universidade Federal do Rio Grande do Sul, Brazil

关键词: polymorphism;    single nucleotide;    tumor necrosis factor receptor;    associated peptides and proteins;    critical care.;   

DOI  :  10.1590/S1413-86702011000300009

来源: Contexto

【 摘 要 】

BACKGROUND: The susceptibility to adverse outcome from critical illness (occurrence of sepsis, septic shock, organ dysfunction/failure, and mortality) varies dramatically due to different degrees of inflammatory response. An over expression of tumor necrosis factor alpha (TNF-α) can lead to the progression of the inflammatory condition.
OBJECTIVE: We assessed the relationship of the genotype distribution of -308G >A TNF-α polymorphism with regard to the development of sepsis, septic shock, higher organ dysfunction or mortality in critically ill patients.
METHODS: Observational, hospital-based cohort study of 520 critically ill Caucasian patients from southern Brazil admitted to the general ICU of São Lucas Hospital, Porto Alegre, Brazil. Patients were monitored daily from the ICU admission day to hospital discharge or death, measuring SOFA score, sepsis, and septic shock occurrences. The -308G >A TNF-α SNP effect was analyzed in the entire patient group, in patients with sepsis (349/520), and in those who developed septic shock (248/520).
RESULTS: The genotypic and allelic frequencies were -308GG = 0.72; -308GA = 0.27; -308AA = 0.01; -308G = 0.85; -308A = 0.15. No associations were found with sepsis, septic shock, organ dysfunction, and/or mortality rates among the TNF-α genotypes. Our results reveal that the -308G >A TNF-α SNP alone was not predictive of severe outcomes in critically ill patients.
CONCLUSION: The principal novel input of this study was the larger sample size in an investigation with -308G > A TNF-α SNP. The presence of -308A allele is not associated with sepsis, septic shock, higher organ dysfunction or mortality in critically ill patients.

【 授权许可】

CC BY-NC-ND