Quality control of human biological material for use in research

Revista de la Universidad Industrial de Santander. Salud

Corzo-Prada, Laura E.²  Páez-Leal, María C.²  Guío-Mahecha, Elizabeth¹  Serrano-Díaz, Norma¹  Luna-González, María L.²  Becerra-Bayona, Silvia² 

[1] Fundación Cardiovascular de Colombia FCV, Bucaramanga, Colombia;Universidad Autónoma de Bucaramanga UNAB, Bucaramanga, Colombia

关键词: Biobank;    biocollections;    pre-analytical variables;    metabolites;    biomarkers;    quality control;    traceability;    human biological material.;   

DOI  :  10.18273/revsal.v48n3-2016013

学科分类：医学（综合）

来源: Universidad Industrial de Santander

【 摘 要 】

Human biological material provides valuable information about levels of metabolites associated with the development of certain diseases, becoming an important tool for monitoring responses to treatment or even identifying new intervention mechanisms. The procedures to what the biological material are exposed from their preparation to their analytical phase are called pre-analytical variables, which can have a direct effectthe detection of metabolites, and therefore, on the results of the research projects, particularly in the absence of standardized processes that confirm the quality control of the biological material. This technical note highlights some critical points that must be parameterized in the biocollections for research purposes to ensure high standards of quality and reproducibility in observational studies, where any kind of bias caused by the pre-analytical variables is minimized. In addition, it is intended to identify the importance of the development of biobanks for research purposes in our country in order to have human biological material of high quality.

【 授权许可】

Unknown