Analysis of the Mechanism for the Development of Allergic Skin Inflammation and the Application for Its Treatment: Overview of the Pathophysiology of Atopic Dermatitis

Journal of Pharmacological Sciences

Tadashi Terui¹ 

[1] Department of Dermatology, Nihon University School of Medicine, Japan

关键词: atopic dermatitis;    nonatopic dermatitis;    barrier dysfunction;    filaggrin;    IgE autoantibody;    allergic inflammation;   

DOI  :  10.1254/jphs.09R02FM

学科分类：药学

来源: Nihon Yakuri Gakkai Henshuubu / Japanese Pharmacological Society

【 摘 要 】

References(19)Cited-By(12)It has been recognized that atopic dermatitis (AD) involves allergen-driven Th2 cell polarization. In patients with AD, cytokines induce allergic inflammatory responses and subsequently enhance IgE production. Recent reports revealed that a reduced barrier function as well as altered immunity are fundamental to the development of AD because barrier disruption due to aberrant filaggrin expression is a pathological factor. However, although recent studies have improved our understanding of the pathogenesis of AD, the overall pathophysiology remains elusive. I herein discuss it based on the natural history of AD.

【 授权许可】

Unknown