Comparison of the effects of long-term pimobendan and benazepriladministration in normal cats

Journal of Veterinary Medical Science

Yuichi MIYAGAWA¹  Noboru MACHIDA²  Noriko TODA¹  Yoshinori TOMINAGA¹  Naoyuki TAKEMURA¹ 

[1] Division of Therapeutic Sciences I, Department of Veterinary Clinical Medicine, School of Veterinary Medicine, Faculty of Veterinary Science, Nippon Veterinary and Life Science University, 1�?7�?1 Kyonan Cho, Musashino City, Tokyo 180�?8602, Japan;Department of Veterinary Clinical Oncology, Tokyo University of Agriculture and Technology, 3�?5�?8 Saiwai-cho, Fuchu, Tokyo 183�?8509, Japan

关键词: angiotensin-converting-enzyme inhibitor;    healthy cat;    mitral valve;    pimobendan;   

DOI  :  10.1292/jvms.14-0673

学科分类：兽医学

来源: Japanese Society of Veterinary Science

【 摘 要 】

References(22)Pimobendan (PIMO) can cause adverse effects, such as mitral valve degeneration, in dogs;however, it is unclear whether these effects occur in cats. Therefore, we aimed todetermine whether PIMO or benazepril produces adverse cardiac effects in healthy cats.This was a blinded, randomized, prospective parallel study. Twelve cats were randomlydivided into two groups of six cats, namely, an angiotensin-converting-enzyme inhibitorgroup that received benazepril and a PIMO group. Cats were administered their respectivetreatments for 506 days, and we evaluated cardiac parameters, blood biochemistry andglomerular filtration rates during that time. At the end of the trial, the cats wereeuthanized, and histopathological examinations were performed by a pathologist who wasblinded to the treatment groups. No significant changes were observed in any of theparameters measured in either of the groups. In particular, no significant cardiac lesionswere observed in either of the groups. In healthy cats, neither PIMO nor benazeprilappears to cause cardiac lesions, but future studies are needed to examine the effects ofPIMO in cats with heart disease.

【 授权许可】

Unknown