Effects of Antihypertensive Drugs on Maternal and Fetal Hemodynamics and Uterine Blood Flow in Pregnant Goats : Comparison of Nicardipine and Labetalol

Journal of Veterinary Medical Science

Yoshio MATSUDA¹  Kazuhiro MISUMI¹  Hiroshi SAKAMOTO¹  Tsuyomu IKENOUE¹ 

关键词: fetal hemodynamics;    labetalol;    nicardipine;    uterine blood flow;   

DOI  :  10.1292/jvms.58.515

学科分类：兽医学

来源: Japanese Society of Veterinary Science

【 摘 要 】

References(13)This study was designed to compare the effects of nicardipine (0.02 mg/kg) and labetalol (0.5 mg/kg) on the uterine blood flow and fetal circulation after intravenous administration in unanesthetized, chronically instrumented pregnant goats. Significant decreases in maternal blood pressure and uterine blood flow were observed in both groups. The maternal heart rate increased significantly after the injection of nicardipine, whereas this change was not observed after the labetalol injection. The fetal heart rate, blood pressure and acid-base status did not change after the injection of either nicardipine or labetalol. These observations in pregnant goats suggest that both nicardipine and labetalol might be useful drugs for the treatment of acutely hypertensive crises in pregnant patients.

【 授权许可】

Unknown