β-Arrestin-Mediated Signaling Improves the Efficacy of Therapeutics

Journal of Pharmacological Sciences

Hitoshi Kurose¹  Islam A.A.E.-H. Ibrahim¹ 

[1] Department of Pharmacology and Toxicology, Graduate School of Pharmaceutical Sciences, Kyushu University, Japan

关键词: G protein-coupled receptor;    biased agonist;    β-arrestin;    G protein;   

DOI  :  10.1254/jphs.11R10CP

学科分类：药学

来源: Nihon Yakuri Gakkai Henshuubu / Japanese Pharmacological Society

【 摘 要 】

References(33)Cited-By(5)β-Arrestins (β-arrestin-1 and β-arrestin-2) were first identified as proteins that have the ability to desensitize G protein-coupled receptors (GPCRs). However, it has recently been found that β-arrestins can activate signaling pathways independent of G protein activation. The diversity of these signaling pathways has also been recognized. This leads to an appreciation of β-arrestin-biased agonists, which is a new class of drugs that selectively activate β-arrestin-mediated signaling without G protein activation. In this review, we will discuss the recent advance of β-arrestin-mediated signaling pathways, including a brief account of different biased agonists, their pharmacological applications, and novel β-arrestin research.

【 授权许可】

Unknown