Regional Differences in Prevalence of Macrolide Resistance among Pediatric Mycoplasma pneumoniae Infections in Hokkaido, Japan

Japanese Journal of Infectious Diseases

Atsuko Horino⁹  Naoko Koseki¹²  Tsuyoshi Kenri⁹  Miki Kaiho¹²  Naoko Nagano^1,5  Hokkaido Pediatric Respiratory Infection Study Group¹  Masanori Nakanishi⁸  Koji Oba¹¹  Toru Watanabe^1,4  Kyosuke Hazama²  Takehiro Togashi¹⁰  Nobuhisa Ishiguro¹²  Hideaki Kikuta^1,7  Satoshi Sasaki³  Tadashi Ariga¹²  Keisuke Morita⁶ 

[1] Hazama Pediatric Clinic;Department of Pediatrics, Aiiku Hospital;Watanabe Pediatric Allergy Clinic;Nagano Pediatric Clinic;Department of Pediatrics, Japanese Red Cross Asahikawa Hospital;Pediatric Clinic, Touei Hospital;Deparment of Pediatrics, Kushiro Red Cross Hospital;Department of Bacteriology II, National Institute of Infectious Diseases;Sapporo City University School of Nursing;Department of Biostatistics, School of Public Health, Graduate School of Medicine, and Interfaculty Initiative in Information Studies, Graduate School of Interdisciplinary Information Studies Library, The University of Tokyo;Department of Pediatrics, Hokkaido University Graduate School of Medicine

关键词: Mycoplasma pneumoniae;    macrolide resistant;    regional difference;    Japan;   

DOI  :  10.7883/yoken.JJID.2015.054

学科分类：传染病学

来源: National Institute of Infectious Diseases

【 摘 要 】

References(27)Cited-By(5)Recently, macrolide-resistant (MR) Mycoplasma pneumonia appeared, and prevalence of macrolide resistance among M. pneumoniae infections varies by country. However, reports on regional differences in the prevalence of MR M. pneumonia within a country are scarce. In this study, 617 nasopharyngeal swab samples were collected from 617 pediatric patients, and DNA of M. pneumoniae was identified in 95 samples. In 51 of the 95 M. pneumonia positive samples, we detected the presence of mutation A2063G mutation (conferring macrolide resistance) in the 23S rRNA gene. The overall macrolide resistance rate was 53.7%, but there were regional differences: 0.0% in Muroran, 5.3% in Asahikawa, 55.3% in Sapporo, and 100.0% in Kushiro. Statistically significant pairwise differences in the prevalence of MR M. pneumoniae were observed among these cities except for the pair of Muroran and Asahikawa. After exclusion (in order to avoid the influence of macrolides) of patients who were prescribed macrolides before collection of nasopharyngeal swab samples, statistically significant differences persisted: 0.0% in Muroran, 5.6% in Asahikawa, 38.5% in Sapporo, and 100.0% in Kushiro.

【 授权许可】

Unknown