Rathke's Cleft Cyst with Short-Term Size Changes in Response to Glucocorticoid Replacement

Endocrine Journal

Naoko OGAMI¹  Kozo HASHIMOTO¹  Hiromichi NAKABAYASHI¹  Hiroshi MARUYAMA¹  Makoto TSUGITA¹  Koichi ASABA¹  Keiji SHIMIZU¹  Toshihiro TAKAO¹  Yasumasa IWASAKI¹ 

[1] Departments of Endocrinology, Metabolism, and Nephrology, and Neurosurgery, Kochi Medical School, Kochi University

关键词: Rathke's cleft cyst;    Pituitary tumor;    Hypopituitarism;    Glucocorticoid;   

DOI  :  10.1507/endocrj.K07E-070

学科分类：内分泌与代谢学

来源: Japan Endocrine Society

【 摘 要 】

References(11)Cited-By(7)An 81-year-old man was admitted to our hospital because of general fatigue. Hormonal examination showed that he had panhypopituitarism and central diabetes insipidus. MRI imaging revealed the presence of large cystic mass with suprasellar extension in his hypothalamo-pituitary region. Interestingly, the cystic mass shrank following the start of glucocorticoid replacement, and since then relatively high doses of cortisol administration were needed to prevent the re-enlargement of cystic size. Because of the concern over possible side effects of supraphysiological doses of glucocorticoid replacement, surgical treatment was eventually carried out, confirming the pathological feature of Rathke's cleft cyst. The present case suggests that the inflammatory nature of Rathke's cleft cyst may explain the observed short-term size changes in response to glucocorticoid administration.

【 授权许可】

Unknown