Effect of Cysteine Derivatives Administration in Healthy Men Exposed to Intense Resistance Exercise by Evaluation of Pro-Antioxidant Ratio

The Journal of Physiological Sciences

Agnieszka Zembron-Lacny²  Kazimierz Szyszka²  Zbigniew Szygula¹ 

[1] Department of Sport Medicine, University of Physical Education Krakow;Department of Sport Medical Sciences, Faculty of Physical Culture, University of Physical Education Poznan

关键词: oxidative stress;    N-acetylcysteine;    α-lipoic acid;    taurine;    athletes;   

DOI  :  10.2170/physiolsci.RP009307

学科分类：生理学

来源: Springer

【 摘 要 】

References(31)Cited-By(5)The aim of this study was to ascertain the influence of cysteine derivatives on pro-antioxidant equilibrium and to compare the antioxidant effectiveness of N-acetylcysteine, α-lipoic acid, and taurine by using Loverro’s coefficient (pro-antioxidant ratio) in healthy men exposed to intensity-resistance exercise. Fifty-five men were randomly assigned to one of four groups: control (CON, placebo), N-acetylcysteine (NAC 1.8 g·day−1, 3 days), α-lipoic acid (LIP 1.2 g·day−1, 3 days), or taurine (TAU 3 g·day−1, 3 days). The erythrocyte superoxide dismutase (SOD), glutathione peroxidase (GPx), and catalase (CAT) activities, lipid peroxidation products (TBARS), and plasma protein thiol concentrations were evaluated. The P/A ratio was determined from the mean values of TBARS, SOD, GPx, and CAT. The applied exercise at maximal intensity induced the significant changes in pro-antioxidant equilibrium toward peroxidation, which was proved by a 25% increase in TBARS concentration in the CON group. The peroxidation was significantly diminished by NAC (–14%) and LIP (–16%), whereas TAU had no effect on the TBARS concentration. Cysteine derivatives administration prevented exercise-induced decline in SOD activity and increased in GPx activity during exercise. CAT activity changed only in the LIP group. The estimation of P/A ratio showed the lowest level of pro-antioxidant equilibrium after LIP administration. In the CON group, P/A ratio was directly correlated with the protein thiols level (r = 0.495, p < 0.001). These data confirm the antioxidant action of tested cysteine derivatives, particularly lipoic acid, and demonstrate the practical application of P/A ratio to evaluate the effectiveness of antioxidants in athletes.

【 授权许可】

Unknown