Flumequine in Atlantic salmon Salmo salar: disposition in fish held in sea water versus fresh water

Diseases of Aquatic Organisms

Magne K. Hansen¹  Tor Einar Horsberg¹  William L. Hayton¹  Sidsel Sohlberg¹  Kristian Ingebrigtsen¹ 

关键词: Flumequine;    Kinetics;    Whole-body autoradiography;    Atlantic salmon;   

DOI  :  10.3354/dao049039

学科分类：生物科学（综合）

来源: Inter-Research

【 摘 要 】

ABSTRACT: ¹⁴C-labeled flumequine was administered as a single oral (5 mg kg^-1, 86 µCi kg^-1) or intravenous (5 mg kg^-1, 82 µCi kg^-1) dose to Atlantic salmon Salmo salar held in sea water or infresh water. The absorption, tissue distribution and elimination were determined by means of liquid scintillation counting and whole-body autoradiography. The drug was rapidly absorbed and extensively distributed in all groups of fish. Radiolabeledcompound was present in blood and muscle for more than 8 wk in the freshwater groups. In the seawater groups, however, no radioactivity was detected in the blood and muscle after 4 d and 2 wk, respectively. It was concluded that flumequine was eliminatedat a substantially higher rate from Atlantic salmon in sea water than in fresh water.

【 授权许可】

Unknown