Deficiency of glucose-6-phosphate dehydrogenase in healthy men and malaria patients; Turbo (Antioquia, Colombia)

Revista Brasileira de Epidemiologia

Álvarez, Gonzalo¹  Carmona-Fonseca, Jaime¹  Vásquez, María Fernanda¹  Ríos, Alexandra¹ 

[1] Universidad de Antioquia

关键词: Glucose-6-phosphate dehydrogenase;    Malaria;    Plasmodium;    Ethnic group;    Sex;    Primaquine;    Colombia;   

DOI  :  10.1590/S1415-790X2008000200007

学科分类：过敏症与临床免疫学

来源: SciELO

【 摘 要 】

INTRODUCTION:Glucose-6-phosphate dehydrogenase (G6PD) deficiency in Latin America has notbeen fully studied and in Colombia only three outdated publications are known.Recent information on the prevalence of G6PD deficiency is required now, becausethe recommended treatment of vivax malaria requires higher daily or total dosesof primaquine.
OBJECTIVE: To measure the prevalence of G6PD in a healthy male populationand in a Plasmodium vivax infected population in Turbo (Urabá,Antioquia Department, Colombia).
METHOD: Prevalence survey to evaluate G6PD in two populations of Turbo(Antioquia): healthy male; male and female with vivax malaria. The work wascarried out on population samples selected using statistical and epidemiologicalcriteria. Enzyme activity was measured using Beutler's normalized method toevaluate G6PD after hemolysis.
RESULTS: For the healthy male group (n = 508), and with a 95% confidenceinterval (IC95%), the mean values were between 4.15 and 4.51 IU/g hemoglobin;14.8% exhibited values below "normal", i.e. < 2.29 IU/g hemoglobin (G6PDprevalence). Among malaria-infected men (n = 206) IC95% ranged from 3.81 to4.16, and among malaria infected women, it ranged from 3.86 to 4.20 IU/g ofhemoglobin. The mean values observed in males (healthy vs. infected) were statisticallydifferent (p = 0.028). Only 9.5% (13/137) of the infected individuals, had G6PDdeficiency and this occurred only within the male group.
CONCLUSIONS: G6PD is relatively high among healthy people (14.8%) andin the P. vivax infected (9.5%) male population of Turbo.

【 授权许可】

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