Localization of connexin 32 in spontaneous liver lesions ofmice

Journal of Veterinary Medical Science

Kazuhisa FURUHAMA²  Toshihiko MAKINO¹  Wataru TAKASAKI¹  Hiroshi SATOH²  Isao IGARASHI¹  Kiyonori KAI¹  Munehiro TERANISHI¹ 

[1] Medicinal Safety Research Laboratories, Daiichi Sankyo Co., Ltd., Kitakasai, Edogawa, Tokyo 134�?8630, Japan;Cooperative Department of Veterinary Medicine, Iwate University, Morioka, Iwate 020�?8550, Japan

关键词: connexin;    immunohistochemistry;    liver lesion;    mouse;   

DOI  :  10.1292/jvms.14-0437

学科分类：兽医学

来源: Japanese Society of Veterinary Science

【 摘 要 】

References(18)We examined the localization of connexin 32 (Cx32), a component of gapjunctions, in 24-month-old male B6C3F1 mice with spontaneously occurring hepatocellularaltered foci or tumors. Immunohistochemically, Cx32-staining intensity in cell-to-cellmembranes of altered hepatocytes was decreased in eosinophilic foci and increased inbasophilic foci as compared to those in intact hepatocytes. These alterations wereenhanced in adenomas and carcinomas with both eosinophilic and basophilic cytoplasm. Incell membranes facing on the sinusoidal portions, the intensities increased in alllesions. Image analyses confirmed that the spot areas of Cx32 were decreased ineosinophilic foci, but increased in basophilic foci, adenomas and carcinomas. Theseresults demonstrate that Cx32 shows different expression in different types of hepaticlesions.

【 授权许可】

Unknown