Circadian Oscillation of 64-kDa Polypeptide in the Rat Suprachiasmatic Nucleus

Journal of Veterinary Medical Science

Haruto KURODA¹  Noboru MURAKAMI¹  Tetsuo NASU¹  Rikako NISHI¹  Teiichi ETOH¹  Nobuyuki MARUMOTO¹ 

关键词: circadian rhythm;    suprachiasmatic nucleus;   

DOI  :  10.1292/jvms.56.161

学科分类：兽医学

来源: Japanese Society of Veterinary Science

【 摘 要 】

References(20)In cell suspensions of suprachiasmatic nucleus harvested every 3 hr from rats kept under 12 hr: 12 hr light-dark cycle and constant darkness, we have detected a Mr 64-kDa protein whose synthesis exhibits two distinct daily peaks in SDS-PAGE. Analysis of densitometer tracings revealed that the synthesis of other proteins was independent of the time of day or not reproducible. Maximum synthesis of the 64-kDa polypeptide occurred at around CT6 and CT21, which are almost coincident with the phase advance regions of circadian activity rhythm induced by anisomycin and light pulses [15], respectively. These results suggest that the 64-kDa protein in SDS-PAGE may be a part of the circadian clock mechanism.

【 授权许可】

Unknown