Association of serum adiponectin with asthma and pulmonary function in the Japanese population

Endocrine Journal

Kotaro Tokui¹  Mika Kigawa⁴  Yutaka Kamura¹  Yukio Kawagishi³  Kenta Kambara¹  Kazuyuki Tobe¹  Minehiko Inomata¹  Chihiro Taka¹  Yasuko Hayashikawa¹  Minoru Iwata¹  Toru Yamada¹  Ryuji Hayashi¹  Teruyo Okazawa¹  Seisuke Okazawa¹  Shoko Matsui² 

[1] First Department of Internal Medicine, Faculty of Medicine, Toyama University, Toyama 930-0194, Japan;Health Administration Center, University of Toyama, Toyama 930-0194, Japan;Internal Medicine, Kurobe City Hospital, Kurobe 938-8502, Japan;Department of Public Health, Faculty of Medicine, University of Toyama, Toyama 930-0194, Japan

关键词: Asthma;    Low molecular weight adiponectin;    Middle molecular weight adiponectin;    Total adiponectin;    Pulmonary function;   

DOI  :  10.1507/endocrj.EJ14-0626

学科分类：内分泌与代谢学

来源: Japan Endocrine Society

【 摘 要 】

References(55)Cited-By(2)Conflicting findings have been reported regarding the role of adiponectin in asthma. The aim of this study was to evaluate the association of adiponectin with pulmonary functions and asthma in the Japanese population. First, among a general population that participated in a previous study (group 1), we selected 329 subjects after excluding those with asthma, chronic obstructive pulmonary disease, and a smoking history and examined the associations of the serum total adiponectin levels with pulmonary functions. In a second cohort (group 2) consisting of 61 asthmatic patients and 175 control non-asthmatic subjects, we examined the associations between asthma and the levels of total, high (HMW), middle (MMW) and low (LMW) molecular weight adiponectin isoforms as well as the ratio of each isoform to total adiponectin level. Although the total adiponectin levels were not significantly different between the asthmatic and control subjects in group 2, the levels were significantly and positively associated with the forced expiratory volume in 1 s after adjustments for confounding factors (P < 0.05) in women in group 1. In group 2, the LMW adiponectin level was significantly higher and the MMW/total adiponectin ratio was significantly lower among the asthmatic subjects than among the control subjects after adjustments for confounding factors in both sexes (P < 0.05). The present study showed that a low total adiponectin level may lead to airway narrowing compatible with asthmatic airways in women, and higher LMW adiponectin levels and lower MMW/total adiponectin ratio are significantly associated with current asthma in both sexes.

【 授权许可】

Unknown