Synthesis, Spectroscopic Characterization and Biological Activity of N-1-Sulfonylcytosine Derivatives

Croatica Chemica Acta

Štambuk, Nikola¹  Glavaš-Obrovac, Ljubica¹  Kašnar-Šamprec, Jelena¹  Mihaljević, Ivica¹  Žinić, Biserka¹  Konjevoda, Paško¹  Mrljak, Vladimir¹  Pavlak, Marina¹ 

关键词: N-1-sulfonylcytosine derivatives: in vitro antiproliferative effect;    antitumor activity;    hematological findings;   

DOI  :  

学科分类：化学（综合）

来源: Croatica Chemica Acta

【 摘 要 】

Large scale preparation of N-1-sulfonylcytosine derivatives has been optimized. The best method was the condensation reaction of silylated cytosine (1) with p-toluenesulfonyl chloride in acetonitrile. Depending on the isolation...

【 授权许可】

Unknown