Serum pepsinogen I/II ratio is correlated with albuminuria in patients with type 2 diabetes

Endocrine Journal

Masahiro Yamazaki²  Emi Ushigome²  Goji Hasegawa²  Michiaki Fukui²  Takafumi Senmaru²  Masaaki Kuroda¹  Naoto Nakamura²  Naoko Nakanishi²  Yusuke Mineoka²  Kazumi Sakabe²  Muhei Tanaka²  Mai Asano² 

[1] Department of Gastroenterology, Yamashiro Public Hospital, Kizugawa 619-0214, Japan;Department of Endocrinology and Metabolism, Kyoto Prefectural University of Medicine, Graduate School of Medical Science, Kyoto 602-8566, Japan

关键词: Pepsinogen;    Albuminuria;    Nephropathy;    Type 2 diabetes;   

DOI  :  10.1507/endocrj.EJ12-0244

学科分类：内分泌与代谢学

来源: Japan Endocrine Society

【 摘 要 】

References(21)Cited-By(1)Helicobacter pylori infection, which is a common cause of atrophic gastritis, has been reported to represent a causal factor increasing the vascular damage and consequent albuminuria.On the other hand, decreased serum pepsinogen (PG) I/II ratio can be used to assess gastric mucosal atrophy.To the best of our knowledge, there are no studies investigating the correlation between PG I/II ratio and diabetic nephropathy.Therefore, we investigated a relationship between PG I/II ratio and degree of urinary albumin excretion (UAE) in patients with type 2 diabetes.We evaluated relationships between PG I/II ratio and degree of UAE or estimated glomerular filtration rate as well as various factors, including age, body mass index, blood pressure, hemoglobin A1c, serum lipid concentrations, uric acid or C-reactive protein in 333 consecutive patients with type 2 diabetes.PG I/II ratio correlated positively with logarithm of UAE in all patients (r = 0.174, P = 0.0016) and in patients without Helicobacter pylori infection (r = 0.352, P P = 0.0005) and in patients without Helicobacter pylori infection (β= 0.295, P = 0.0022).These data suggest that serum PG I/II ratio is correlated with diabetic nephropathy.

【 授权许可】

Unknown