Novel Findings for the Development of Drug Therapy for Various Liver Diseases: Current State and Future Prospects for Our Liver Regeneration Therapy Using Autologous Bone Marrow Cells for Decompensated Liver Cirrhosis Patients

Journal of Pharmacological Sciences

Taro Takami¹  Isao Sakaida²  Shuji Terai² 

[1] Division of Laboratory, Yamaguchi University Hospital, Japan;Department of Gastroenterology & Hepatology, Yamaguchi University Graduate School of Medicine, Japan

关键词: liver cirrhosis;    bone marrow;    stem cell;    liver regeneration;    autologous bone marrow cell infusion (ABMi) therapy;    liver disease;   

DOI  :  10.1254/jphs.10R13FM

学科分类：药学

来源: Nihon Yakuri Gakkai Henshuubu / Japanese Pharmacological Society

【 摘 要 】

References(21)Cited-By(7)We have developed an in vivo mouse model [the green fluorescent protein (GFP) / carbon tetrachloride (CCl4) model] and reported that infused GFP-positive bone marrow cells administered via a tail vein efficiently repopulated cirrhotic liver tissue under conditions of persistent liver damage induced by CCl4. Moreover, bone marrow cells infused into the liver improved liver function and ameliorated liver fibrosis with higher expression of matrix metalloproteinase 9 (MMP-9), consistent with improved survival rate. Based on these findings, we started a multicenter clinical trial of autologous bone marrow cell infusion (ABMi) therapy for decompensated liver cirrhosis patients and demonstrated the efficacy of this approach without unexpected complications. However, this therapy involves bone marrow aspiration under general anesthesia and is not indicated for patients for whom general anesthesia is difficult. We therefore aimed to develop a new liver regeneration therapy in which cells having a curative effect on liver cirrhosis are isolated and cultured from a small amount of autologous bone marrow aspirated under local anesthesia and infused back into the same subject. Herein, we present results for the GFP/CCl4 model and ABMi therapy and future prospects for a new liver regeneration therapy.

【 授权许可】

Unknown