Protective Effect of Humus Extract Against Trypanosoma brucei Infection in Mice

Journal of Veterinary Medical Science

DENSO¹  Hiroshi KODAMA¹  Saeko ISHIDA¹  Fumi OKAZAKI¹ 

[1] Laboratory of Veterinary Immunology, Course of Veterinary Science, Graduate School of Life and Environmental Sciences, Osaka Prefecture University

关键词: humic substance;    Interferon-γ;    lymphocyte activation;    protection;    Trypanosoma brucei;   

DOI  :  10.1292/jvms.70.1185

学科分类：兽医学

来源: Japanese Society of Veterinary Science

【 摘 要 】

References(25)Cited-By(5)Humic substances are formed during the decomposition of organic matter in humus, and are found in many natural environments in which organic materials and microorganisms are present. Oral administration of humus extract to mice successfully induced effective protection against experimental challenge by the two subspecies, Trypanosoma brucei brucei and T. brucei gambiense. Mortality was most reduced among mice who received a 3% humus extract for 21 days in drinking water ad libitum. Spleen cells from humus-administered mice exhibited significant non-specific cytotoxic activity against L1210 mouse leukemia target cells. Also, spleen cells produced significantly higher amounts of Interferon-γ when stimulated in vitro with Concanavalin A than cells from normal controls. These results clearly show that administration to mice of humus extract induced effective resistance against Trypanosoma infection. Enhancement of the innate immune system may be involved in host defense against trypanosomiasis.

【 授权许可】

Unknown