Retrospective Analysis of 18 Cases of Antithyroid Drug (ATD)-Induced Agranulocytosis

Endocrine Journal

BAO-ZHEN XU⁴  YANG YAO⁶  WEI-XIN DAI²  HONG JIN⁷  WEI-CHANG XIN³  JIAN-DE ZHANG⁵  SHI-WEI ZHAN¹  YAO BAI² 

[1] Endocrinology Department, No. 262 Hospital;Endocrinology Department, Chinese Academy Medicine Sciences and Peking Union Medical College Hospital;Endocrinology Department, Xuan-Wu Hospital;Endocrinology Department, Beijing Army Hospital;Endocrinology Department, Nan-Xi Mountain Hospital;Endocrinology Department, No. 292 Hospital;Endocrinology Department, Beijing Railway Hospital

关键词: Agranulocytosis;    Hyperthyroidism;    Antithyroid drug;   

DOI  :  10.1507/endocrj.49.29

学科分类：内分泌与代谢学

来源: Japan Endocrine Society

【 摘 要 】

References(10)Cited-By(15)In this study, we retrospectively analyzed 18 patients in whom antithyroid drug (ATD)-induced agranulocytosis developed during treatment of Graves' disease. All patients were more than 20 years of age, and we saw no correlation between age and the development of agranulocytosis. In 17 of 18 patients, ATD-induced agranulocytosis developed within 2 to 12 weeks of starting ATD treatment. Development of agranulocytosis was related to the dose of ATD. In some patients, agranulocytosis developed abruptly, and even weekly routine WBC and granulocyte counts failed to predict all case occurrences. Fever and sore throat were the earliest symptoms of agranulocytosis; patients who developed either of these symptoms were closely monitored immediately with WBC and granulocyte count examinations. In this series of patients, treatment with granulocyte-macrophage colony stimulating factor (GM-CSF) increased the granulocyte counts, whereas the effectiveness of glucocorticoid treatment was not confirmed.

【 授权许可】

Unknown