Hyaluronic acid in the evaluation of liver fibrosis in patients with hepatitis C on haemodialysis

Brazilian Journal of Infectious Diseases

Ávila, Renata Eliane de¹  Carmo, Ricardo Andrade³  Lambertucci, José Roberto¹  Antunes, Carlos Maurício de Figueiredo²  Teixeira, Antônio Lúcio¹  Coimbra, Lucas Viana¹  Farah, Kátia de Paula¹ 

[1] Universidade Federal de Minas Gerais;UFMG;Fundação Hemominas

关键词: liver fibrosis;    hyaluronic acid;    end-stage renal disease;    haemodialysis;    hepatitis C.;   

DOI  :  10.1590/S1413-86702010000400004

来源: Contexto

【 摘 要 】

BACKGROUND: This study evaluated the role of HA as a marker of liver fibrosis in patients with hepatitis C on haemodialysis.
METHODS: This is a cross-sectional study in which 52 patients were divided into two groups: Group 1: patients with hepatitis C and end-stage renal disease (ESRD) undergoing haemodialysis (n = 23); and Group 2: patients with hepatitis C without ESRD (n = 29). Plasma levels of HA were associated with histological data of the samples obtained by liver biopsy and classified by METAVIR group scoring system.
RESULTS: Higher plasma levels were significantly correlated to significant liver fibrosis (METAVIR > F2). In Group 1, the HA cutoff to discriminate significant fibrosis was 984.8 ng/mL, with accuracy, sensitivity and specificity of 80.8%, 83.0%, and 70.0%, respectively. In Group 2, the HA cutoff was 222.3 ng/mL, with accuracy, sensitivity and specificity of 74.5%, 70.0%, and 94.0%, respectively.
CONCLUSION: HA was an accurate noninvasive marker in predicting significant fibrosis in patients with hepatitis C on haemodialysis.

【 授权许可】

CC BY-NC-ND