Safety and Efficacy Testing of a Novel Multivalent Bovine Bacterial Respiratory Vaccine Composed of Five Bacterins and Two Immunogens

Journal of Veterinary Medical Science

Jong Man KIM²  Yi-Seok JOO²  Hee Soo LEE²  Sook-Kyoung LIM²  Yun Sang CHO²  Jae Hoon KIM¹ 

[1] Veterinary Pathology Laboratory, Cheju National University;Bacteriology and Parasitology Division, Animal Disease Research Department, National Veterinary Research & Quarantine Service

关键词: Arcanobacterium pyogenes;    Haemophilus somnus;    Mannheimia haemolytica leukotoxoid;    Mycoplasma bovis;    Pasteurella multocida outer membrane protein;   

DOI  :  10.1292/jvms.70.959

学科分类：兽医学

来源: Japanese Society of Veterinary Science

【 摘 要 】

References(20)Cited-By(4)Bovine bacterial respiratory diseases have been one of the most serious problems due to their high mortality and economic loss in calves. The vaccinations of bovine bacterial respiratory vaccines have been complex because of no multivalent vaccine. In this study, novel multivalent bovine bacterial respiratory vaccine (BRV) was developed and tested for its safety and efficacy. BRV was composed of two immunogens and five bacterins. These were leukotoxoid and bacterin of Mannheimia haemolytica type A, outer membrane protein and bacterin of Pasteurella multocida type A, and bacterins of Haemophilus somnus, Mycoplasma bovis, and Arcanobacterium pyogenes. ELISA antibody titers to five bacterial antigens in vaccinated guinea pigs increased, compared with those in unvaccinated ones. BRV was safe for calves and pregnant cattle in this study. In calves challenged with M. haemolytica and P. multocida, the average daily weight gain and antibody titers of vaccinated calves increased, and respiratory symptoms (P<0.05) and treatment frequency (P<0.01) of vaccinated calves significantly decreased, compared with those of unvaccinated calves. Interestingly, the antibody titers of M. haemolytica leukotoxoid and Mycoplasma bovis were closely related with the reduction of respiratory symptoms. BRV would be an ecomonical measure for the protection against bovine bacterial respiratory diseases.

【 授权许可】

Unknown