Nobiletin, a Citrus Flavonoid That Improves Memory Impairment, Rescues Bulbectomy-Induced Cholinergic Neurodegeneration in Mice

Journal of Pharmacological Sciences

Si-Young Song²  Tohru Yamakuni³  Chieko Kato²  Mitsuya Haraguchi³  Yutaka Sashida¹  Naoki Omae³  Yasushi Ohizumi³  Akihito Yokosuka¹  Takeshi Tadano⁴  Akira Nakajima³  Osamu Nakagawasai⁴  Yoshihiro Mimaki¹ 

[1]Laboratory of Medicinal Plant Science, School of Pharmacy, Tokyo University of Pharmacy and Life Science, Japan

[2]Institute of Neuroscience, Tokushima Bunri University at Kagawa, Japan

[3]Department of Pharmaceutical Molecular Biology, Graduate School of Pharmaceutical Sciences, Tohoku University, Japan

[4]Department of Pharmacology, Tohoku Pharmaceutical University, Japan

关键词: Alzheimer’s disease;    cholinergic neuron;    nobiletin;   

DOI  :  10.1254/jphs.SC0070155

学科分类：药学

来源: Nihon Yakuri Gakkai Henshuubu / Japanese Pharmacological Society

【 摘 要 】

References(15)Cited-By(61)We have recently reported that nobiletin, a citrus flavonoid, improves impaired memory in olfactory-bulbectomized (OBX) mice, which have been widely utilized as a useful paradigm that shares some major clinical features of Alzheimer’s disease. Here, we examined the effects of nobiletin on OBX-induced cholinergic neurodegeneration in mice. OBX mice showed reduced acetylcholinesterase (AChE) staining and choline acetyltransferase (ChAT) expression in the hippocampus. An 11-day administration of nobiletin rescued OBX-induced decrease in the density of AChE-staining and ChAT expression in the hippocampus. These results suggest that nobiletin rescues OBX-induced cholinergic neurodegeneration, accompanied by improvement of impaired memory in OBX mice.

【 授权许可】

Unknown