Optimizing a process to obtain Ocimum sanctum L. (albaca morada) aqueous extract

Revista Cubana de Plantas Medicinales

López Hernández, Orestes Darío²  Gonzáles Sanabia, María Lidia²  Barzaga Fernández, Pedro²  Carmona Fernández, Rolando²  Fernández Núñez, Eutimio Gustavo¹ 

[1] Centro de Ingeniería e Investigaciones Químicas, Ciudad de La Habana, Cuba;Centro de Investigación y Desarrollo de Medicamentos, Ciudad de La Habana, Cuba

关键词: Ocimum sanctum;    Ocimum tenuiflorum;    albahaca morada;    extracto acuoso;    optimización;   

DOI  :  

学科分类：药理学

来源: Editorial Ciencias Medicas

【 摘 要 】

INTRODUCTION: Ocimum sanctum L. (albahaca morada) is a traditional medicinal herb with hypoglycaemic action and other therapeutic effects. OBJECTIVES: to optimize a technique for obtaining aqueous extract from O. sanctum and to analyze the impact of the process parameters. METHODS: the effect of three variables in the process of obtaining aqueous extract from O. sanctum leaves was studied along with the optimization of this technique on the basis of maximizing the number of total solids present in the extract and the recovery values by using a lab cylindrical reactor with de-scaled geometry of an industrial reactor. The response surface study used hybrid design of eleven experiments, managed to analyze 3 factors at five levels and adequately responded to the need of finding out the impact of the process variables and the optimal extraction values.RESULTS: drug-solvent ratio was the most influential variable, being the most significant in the extraction, although all of them were significant. Also, 100 ºC temperature, drug/solvent ratio (1:11) and three hours for shaking were the optimal operational parameters for the suggested process. CONCLUSIONS: the factors having the highest impact on the process and their significance were found. Additionally, the technique to obtain O. sanctum aqueous extract was optimized by estimating the most adequate values for operational parameters

【 授权许可】

CC BY-NC