Augmentation of the Delayed Rectifier Potassium Current by ETA Endothelin Receptor in Guinea Pig Atrial Myocytes

Journal of Pharmacological Sciences

Kageyoshi Ono¹ 

[1] Division of Xenobiotic Metabolism and Disposition, National Institute of Health Sciences

关键词: ETA endothelin receptor;    delayed rectifier K+ current;    atrium;   

DOI  :  10.1254/jphs.91.79

学科分类：药学

来源: Nihon Yakuri Gakkai Henshuubu / Japanese Pharmacological Society

【 摘 要 】

References(15)The role of ETA endothelin receptor (ETAR) in the regulation of the delayed rectifier potassium current (IK) was examined in guinea pig atrial myocytes. Application of ET-1 (10 nM) together with an ETB-receptor-selective antagonist, BQ-788 (300 nM), significantly increased the voltage-dependent activation of IK without affecting its half-activation voltage or the slope factor, while it suppressed the calcium current (ICaL) and displaced the time-independent background current to the outward direction. The data suggests that the augmentation of IK contributes to the ETA-receptor-mediated shortening of action potential duration, and hence to the negative inotropic response, in atria.

【 授权许可】

Unknown