Gabapentin Prevents Oxaliplatin-Induced Mechanical Hyperalgesia in Mice

Journal of Pharmacological Sciences

Toshiaki Makino²  Hideki Ono¹  Tomoyasu Murakami¹  Saki Otake¹  Shohei Yamamoto¹  Masahiro Ohsawa¹ 

[1] Laboratory of CNS Pharmacology, Graduate School of Pharmaceutical Sciences, Nagoya City University, Japan;Department of Pharmacognosy, Graduate School of Pharmaceutical Sciences, Nagoya City University, Japan

关键词: oxaliplatin;    mechanical allodynia;    gabapentin;    neuropathic pain;    cofilin;   

DOI  :  10.1254/jphs.14058FP

学科分类：药学

来源: Nihon Yakuri Gakkai Henshuubu / Japanese Pharmacological Society

【 摘 要 】

References(47)Cited-By(7)Oxaliplatin, a platinum-based chemotherapy drug, frequently causes acute and chronic peripheral neuropathies including mechanical hyperalgesia. These adverse effects hinder anticancer therapy with the drug. In this study, we examined several drugs that might prevent oxaliplatin-induced peripheral neuropathy. Single intraperitoneal (i.p.) injection of oxaliplatin (10 mg/kg) induced cold allodynia (acetone test) and mechanical hyperalgesia (von Frey test). Gabapentin, but not simvastatin and atorvastatin, prevented oxaliplatin-induced mechanical hyperalgesia without affecting cold allodynia. Moreover, oxaliplatin caused phosphorylation of cofilin protein in the spinal cord, which has been shown to be involved in the neuropathic hyperalgesia. This increased phosphorylation of cofilin was also attenuated by gabapentin treatment. These results suggest that gabapentin is useful for relieving oxaliplatin-induced mechanical hyperalgesia and that the pathogenic mechanisms of cold allodynia and mechanical hyperalgesia differ.

【 授权许可】

Unknown