Functional Residual Capacity and Airway Resistance of the Rat Measured with a Heat- and Temperature-Adjusted Body Plethysmograph

The Journal of Physiological Sciences

Hajime Yamabayashi²  Sakurako Tajiri²  Tetsuri Kondo¹ 

[1] Department of Medicine, Tokai University Hachioji Hospital;Department of Medicine, Tokai University School of Medicine

关键词: functional residual volume;    airway resistance;    rat;    bodyplethysmograph;    obstructive lung disease;   

DOI  :  10.2170/physiolsci.RP004506

学科分类：生理学

来源: Springer

【 摘 要 】

References(33)Cited-By(2)The functional residual capacity (FRC) and airway resistance (Raw) of the rat were measured, using a newly designed body plethysmograph (BPG), the inner environment of which was maintained at body temperature and was water-vapor saturated. The subjects were anesthetized and tracheally intubated male Wistar rats (n = 15). After measuring the FRC and Raw, we analyzed the effects of inhaled methacholine (Mch, 0–8 mg/ml) on Raw.The determined FRC was 5.37 ± 0.22 ml (mean ± SE). An almost linear relationship between box pressure and respiratory flow was obtained when the difference between box-gas temperature and the rectal temperature of the rat was less than 1.0°C. The Raw at FRC was 0.230 ± 0.017 cmH2O/ml/s. It increased proportionally with increases in the Mch concentration. When the dynamic changes in Raw were analyzed, the Raw was found to progressively increase during expiration; this increase continued throughout inspiration. Thus in the rat, Raw is not simply a function of changes in lung volume. In conclusion, the humidity- and temperature-adjusted BPG provided an absolute and possibly dynamic value of Raw.

【 授权许可】

Unknown