Antagonism of Medetomidine Sedation by Atipamezole in Pigs

Journal of Veterinary Medical Science

Satoru MATSUNAGA¹  Minoru SAKAGUCHI¹  Hwiyool KIM¹  Akira TAKEUCHI¹  Nobuo SASAKI¹  Ryohei NISHIMURA¹  Hiroshi TAMURA¹ 

关键词: atipamezole;    medetomidine;    pig;   

DOI  :  10.1292/jvms.54.1237

学科分类：兽医学

来源: Japanese Society of Veterinary Science

【 摘 要 】

References(6)Cited-By(4)The efficacy of atipamezole as a medetomidine antagonist was evaluated in pigs. The atipamezole doses (intramuscularly) were 80, 160, 320 and 480 μg/kg of body weight, which were one, two, four and six times higher than the preceding medetomidine dose (80 μg/kg, intramuscularly). Atipamezole effectively reversed medetomidine-induced sedation, and the optimal action was seen at doses of 160 and 320 μg/kg. Recovery from sedation was quick and smooth, and adverse effects such as hyperactivity or tachycardia were minimal with either dose.

【 授权许可】

Unknown