Carcinoma of Unknown Primary – an Orphan Disease?

Breast care

Gerdt Hübner¹  Alwin Krämer¹  Kai Neben¹  Gunnar Folprecht¹  Andreas Schneeweiss¹ 

[1] aKlinische Kooperationseinheit für Molekulare Hämatologie und Onkologie des Deutsches Krebsforschungszentrums und der Medizinischen Klinik und Poliklinik V der Universität Heidelberg, Germany

关键词: CUP;    Carcinoma of unknown primary;    Metastases;    Cetuximab;   

DOI  :  10.1159/000136001

学科分类：泌尿医学

来源: S Karger AG

【 摘 要 】

Carcinoma of unknown primary (CUP) is an intriguing clinical finding that is defined as biopsy-proven metastasis from a malignancy in the absence of an identifiable primary site after a complete clinical work-up. CUP is a relatively common clinical entity, accounting for approximately 3–5% of all cancer diagnoses, and consists of a heterogeneous group of tumors that have acquired the capacity to metastasize before the development of a clinically evident primary lesion. Notable advances have been made over the past years in the treatment of well-defined clinical subgroups of CUP, such as women with peritoneal carcinomatosis and young adults with poorly differentiated carcinomas of midline distribution, but for the majority of patients, the prognosis still remains poor. In this review, we highlight recent advances in the diagnosis and treatment of patients with CUP syndrome, and emphasize the importance of identifying several favorable subsets of CUP, amenable to specific treatment options. In addition, we will point out novel diagnostic and therapeutic approaches which will hopefully improve both our understanding and the prognosis of this more or less neglected disease.

【 授权许可】

Unknown