KPC-producing Enterobacter aerogenes infection

Brazilian Journal of Infectious Diseases

Cieslinsk, Juliette²  Tuon, Felipe F.²  Becker, Guilherme Nardi²  Rocha, Jaime L.¹  Scharf, Camila²  Arend, Lavinia N.³ 

[1] DASA Medicina Diagnóstica, Curitiba, Brazil;Hospital Universitário Evangélico de Curitiba, Curitiba, Brazil;Laboratório Central do Estado, Curitiba, Brazil

关键词: KPC Enterobacter;    Carbapenemase;    Infection control Enterobacter is a microorganism associated with third generation cephalosporins resistance due to overexpression of Amp-C gene;   

DOI  :  10.1016/j.bjid.2015.01.003

来源: Contexto

【 摘 要 】

Background:Enterobacter is a common nosocomial microorganism and its carbapenem's resistance has increased. The management of these cases is unclear. Objective: We evaluated 16 patients with KPC-producing Enterobacter aerogenes infections, detailing the site of infection, therapy, clinical and epidemiological data. Methods: A retrospective and descriptive study. Clinical data were revised and KPC-2 detection was by molecular methods. Risk factors associated with mortality were compared using appropriate tests according to variable type with a significance level of 0.05. Results: The 30-day mortality rate was 37.5% with no association with inadequate treatment. Age (p = 0.004) and Charlson score of comorbidities (p = 0.048) were independent risk factors associated with death in the multivariate analysis. The odds ratio for age >43 years was 3.00 (95% CI: 1.02-9.32) and for Charlson score >3 was 2.00 (95% CI: 1.08-3.71). Five strains were pan-resistant based on automated susceptibility tests. All patients were treated with monotherapy. Conclusion: The clinician should be alert to carbapenem-resistant Enterobacteriaceae infection in older patients with comorbidities. The mortality is high and we believe that prompt and adequate therapy must be employed.

【 授权许可】

Unknown