Orbital magnetic resonance imaging combined with clinical activity score can improve the sensitivity of detection of disease activity and prediction of response to immunosuppressive therapy for Graves’ ophthalmopathy

Endocrine Journal

Akiko Nakashima²  Hitoshi Noguchi⁴  Yasushi Noguchi²  Seigo Tachibana⁴  Yufuko Ohyabu¹  Shiro Noguchi³  Tsukasa Murakami⁴ 

[1] Kitahama eye clinic, Oita, Japan;Department of Radiology, Noguchi Thyroid Clinic and Hospital Foundation, Oita, Japan;Department of Surgery, Noguchi Thyroid Clinic and Hospital Foundation, Oita, Japan;Department of Endoclinology, Noguchi Thyroid Clinic and Hospital Foundation, Oita, Japan

关键词: Orbital MRI;    CAS;    Graves’ ophthalmopathy;    Immunosuppressive therapy;    Glucocorticoid;   

DOI  :  10.1507/endocrj.K10E-156

学科分类：内分泌与代谢学

来源: Japan Endocrine Society

【 摘 要 】

References(20)Cited-By(10)The aim of this study was to demonstrate that the addition of orbital magnetic resonance (MR) imaging can provide improvement in sensitivity of detection of active disease and the prediction of the response to intravenous glucocorticoid therapy (ivGC), over clinical activity score (CAS) alone. A prospective case series was studied at our institution. Forty eight patients were examined by CAS and orbital MR imaging. The maximum of T2 relaxation times of extraocular muscles (maxT2RT) and other parameters were evaluated by MR imaging. Thirty five of 48 patients underwent ivGC. Twenty of 35 patients, whose CAS was 2 points or less, were evaluated for the response to ivGC. The correlation between CAS and maxT2RT was evaluated. Differentiation of active and inactive GO was performed by CAS and orbital MR imaging. The response to ivGC was evaluated by CAS, orbital MR imaging and ophthalmic parameters. As a result, CAS and maxT2RT showed significant positive correlation (r=0.58, p<0.0001), and 15 patients were positive by CAS and orbital MR imaging. However, 20 patients were positive by only MR imaging. In those 20 patients, there was significant improvement after ivGC. We concluded that orbital MR imaging combined with CAS could improve the sensitivity of detection of active disease and the prediction of the response to ivGC. In addition, even if only one parameter of CAS is positive, further examination with orbital MR imaging is advised.

【 授权许可】

Unknown