Pathophysiological Roles of Aldosterone and Mineralocorticoid Receptor in the Kidney

Journal of Pharmacological Sciences

Akira Nishiyama¹  Hirofumi Hitomi¹  Daisuke Nakano¹  Kazi Rafiq¹ 

[1] Department of Pharmacology, Kagawa University Medical School, Japan

关键词: aldosterone;    mineralocorticoid receptor (MR);    renal injury;    eplerenone;    renal blood flow;   

DOI  :  10.1254/jphs.10R07CR

学科分类：药学

来源: Nihon Yakuri Gakkai Henshuubu / Japanese Pharmacological Society

【 摘 要 】

References(64)Cited-By(13)Aldosterone, a steroid hormone, has traditionally been viewed as a key regulator of fluid and electrolyte homeostasis, as well as blood pressure, through the activation of mineralocorticoid receptor (MR). However, a number of studies performed in the last decade have revealed an important role of aldosterone/MR in the pathogenesis of renal injury. Aldosterone/MR-induced renal tissue injury is associated with increased renal inflammation and oxidative stress, fibrosis, mesangial cell proliferation, and podocyte injury, probably through genomic and non-genomic pathways. However, our preliminary data have indicated that acute administration of aldosterone or a selective MR antagonist, eplerenone, does not change blood pressure, heart rate, or renal blood flow. These data suggest that aldosterone/MR induces renal injury through mechanisms that are independent of acute changes in systemic and renal hemodynamics. In this review, we will briefly summarize the roles of aldosterone/MR in the pathogenesis of renal injury, focusing on the underlying mechanisms that are independent of systemic and renal hemodynamic changes.

【 授权许可】

Unknown